Renal stone formation following medical treatment of renal candidiasis.

Two very low birth weight infants who developed renal candidiasis with pelvicalyceal fungal concretions were treated medically with Amphotericin B and 5 Fluorocytosine. Two months following cessation of therapy, the fungal concretions decreased in size, became sterile and developed calcification in residual debris. The calcifications was still present at demise in one patient and at 18 months follow up in the other.

Phagocytosis of Candida albicans in chronic mucocutaneous candidiasis.

Inasmuch as human monocytes are able to kill Candida albicans (C. albicans) only through oxidative pathways, which also produce chemiluminescence (CL), CL was used to assess the ability of polymorphonuclear neutrophils and monocytes to phagocytose and kill C. albicans in a 12-year-old girl with chronic mucocutaneous candidiasis.

Early infantile variant of Krabbe globoid cell leucodystrophy with lung involvement.

An 8-week-old boy presented with a history of irritability, progressive feeding difficulty, generalised weakness, tachypnoea, and minor motor seizures. The clinical course was characterised by rapidly progressive respiratory failure, and neurological deterioration culminating in death at age 15 weeks. Electron microscopical examination and histological studies of the lung showed the presence of numerous intra-alveolar and a few interstitial macrophages.