Publications by authors named "R Owor"
Dog bites are a source of zoonotic infections to humans, such as pasteurellosis and meningitis. Zoonotic bacterial identification and their antibiotic susceptibility assessment are key towards the successful management of such infections. This study isolated and identified zoonotic bacterial species from the oral cavities of indigenous dogs and also determined their antibiotic susceptibility profile.
View Article and Find Full Text PDFClinical Predictors of 3-Months Isoniazid Rifapentine (3HP) - Related Adverse Drug Reactions (ADR) During Tuberculosis Preventive Therapy. (PAnDoRA-3HP study): An Observational Study Protocol.
medRxiv
June 2024
Introduction: Tuberculosis (TB) is the leading infectious cause of death globally. Despite WHO recommendations for Tuberculosis Preventive Therapy (TPT), challenges persist, including incompletion of treatment and adverse drug reactions (ADRs). There is limited data on the 3-month isoniazid and rifapentine (3HP) pharmacokinetics, pharmacogenomics and their relation with ADRs.
View Article and Find Full Text PDFCurrently, highly active antiretroviral therapy is unable to cure HIV/AIDS because of HIV latency. This study aimed at documenting medicinal plants used in the management of HIV/AIDS in Eastern Uganda so as to identify phytochemicals with HIV latency reversing potential. An ethnobotanical survey was conducted across eight districts in Eastern Uganda.
View Article and Find Full Text PDF(Fabaceae) crude extracts are key ingredients of several licensed and unlicensed herbal products in East Africa. However, there is limited and often contradicting information regarding its toxicity. We therefore evaluated the acute and subacute toxicity of the ethanolic stem bark extract of in mature healthy Wistar albino rats following Lorke's method and OECD guidelines 407.
View Article and Find Full Text PDFArticle Synopsis
- The theory of immune regulation focuses on the balance between T-helper 1 (Th1) and T-helper 2 (Th2) immune responses, initially discovered in mice in 1986.
- Th1 cells are responsible for cellular immunity against intracellular pathogens, while Th2 cells handle humoral immunity against extracellular pathogens.
- The review explores how HIV infection can disrupt this balance, detailing insights into the HIV life cycle and mechanisms behind the shift from Th1 to Th2 cells, particularly in the later stages of HIV disease.