Publications by authors named "R Orasan"
Chronic kidney disease (CKD) causes specific hormonal disturbances, such as variations in leptin and testosterone levels and function. These disturbances can promote errors in signaling interaction and cellular information processing and can be implicated in the pathogenesis of atherosclerosis. This study investigates the factors that affect leptin in CKD patients and examines how leptin is related to markers of vascular disease.
View Article and Find Full Text PDFObjective: Psoriasis is a chronic, inflammatory skin disease, requiring local and systemic drugs according to disease severity. This study aims to investigate the efficacy and safety of a topical treatment containing xyloglucan, pea proteins and extracts (XPO) compared to calcipotriol 50mcg/betamethasone 0.5mg ointment (CB).
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- - The study investigated how biologic therapies for psoriasis affect patients’ metabolic and inflammatory conditions by comparing 106 psoriasis patients with a control group over 6 months.
- - Results showed that psoriasis patients initially had higher rates of obesity, metabolic syndrome, and chronic inflammation compared to controls, but after 6 months of biologic therapy, there were significant improvements in metabolic indicators like HDL and levels of inflammation (CRP and ESR).
- - The findings suggest that biologic therapies not only reduce psoriasis severity but also positively influence the metabolic and inflammatory profiles of patients, specifically reducing the prevalence of metabolic syndrome and chronic inflammation.
Introduction: Atopic dermatitis (AD) is a chronic disease that occurs mainly in children. Topical corticosteroids are the main treatment for mild to moderate AD, although they can induce side effects. The efficacy and tolerability of xyloglucan and pea protein (XG-PP) was compared with hydrocortisone in pediatric patients with AD as a steroid-sparing solution.
View Article and Find Full Text PDFCardiovascular diseases (CVD) are the first cause of chronic kidney disease (CKD) mortality. For personalized improved medicine, detecting correctable markers of CVD can be considered a priority. The aim of this study was the evaluation of the impact of nutritional, hormonal and inflammatory markers on brachial-ankle Pulse Wave Velocity (PWV) in pre-dialysis CKD patients.
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