Publications by authors named "R Oguri"
Background: This study aimed to investigate the relationship between low-dose prednisolone (PSL) and the incidence of hypokalaemia at abiraterone acetate (abiraterone) plus PSL combination therapy targeting Japanese patients with metastatic castration-resistant prostate cancer (mCRPC).
Methods: This retrospective observational study included 153 Japanese patients treated with abiraterone and PSL for mCRPC at Kariya Toyota General Hospital and Gifu General Medical Center between September 2014 and October 2022. The incidence of grade ≥ 2 hypokalaemia as well as serum potassium level variations and the continuous combination therapy duration were compared between the low-dose (5 mg/day of PSL) and the standard-dose (10 mg/day of PSL) groups.
Article Synopsis
- - The study explores how different-sized protein aggregates affect the performance of virus removal filters by creating fouling, or blockage, in the filtration process.
- - Human immunoglobulin G was heated to form protein aggregates of various sizes, which were then filtered through the Planova 20N membrane, revealing that larger aggregates tend to collect closer to the membrane surface while smaller ones penetrate deeper.
- - The findings highlight the membrane's gradient structure, which helps minimize fouling by preventing larger aggregates from clogging smaller pores, and they suggest that the clogging behavior evolves from complete blockage to cake filtration over time.
Article Synopsis
- Deleting gene expression in specific tissues helps researchers understand the functions of certain proteins, and the Cre-loxP system is a popular method for this purpose in various organisms, including medaka fish.
- The epithelium, being the outer protective layer, is crucial for studying responses to external stimuli, yet there wasn't a specific Cre-driver line available for it in medaka.
- This study successfully developed epithelium-specific Cre-driver lines using CRISPR/Cas9 technology, targeting periplakin and keratin genes, allowing for efficient gene recombination in epithelial tissues for further research.
Recently, pretreatment with immune checkpoint inhibitors (ICIs) has been shown to enhance the therapeutic effects of the combination therapy of ramucirumab (RAM) and docetaxel (DTX); however, its influence on the drug's side effects remains unclear. This study investigated the influence of pretreatment with ICIs on the incidence of neutropenia caused by RAM + DTX therapy in patients with non-small cell lung cancer (NSCLC). Patients with NSCLC who received RAM + DTX therapy at Gifu Prefectural General Medical Center between April 2016 and December 2020 were enrolled.
View Article and Find Full Text PDFThrombin-deficient mutant of medaka, a model fish, displays serious retardation in blood coagulation.
Biosci Biotechnol Biochem
March 2021
At the last stage of the blood coagulation cascade, thrombin plays a central role in the processing of fibrinogen for the polymerization and in the additional activation of Factor XIII for the stable cross-linking of fibrin. In addition, thrombin carries out possible multiple roles via processing or interaction with various functional proteins. Several studies conducted in order to elucidate additional physiological significance are ongoing.
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