Identification of latent classes of randomized controlled trials based on integrity and reporting characteristics.

Objective: Reliable, well conducted and adequately reported research is essential for decision-making. This study uses an exploratory clustering approach to identify patterns (subgroups) of trials based on research conduct and reporting characteristics to better understand heterogeneity. Describing features of these subgroups may help elucidate mechanisms of poor planning and reporting that can be acted upon by the research community to improve the research practices.

Many randomized trials in a large systematic review were not registered and had evidence of selective outcome reporting: a metaepidemiological study.

Objectives: The primary objectives were to describe characteristics of trial registration in the chronic low back pain (CLBP) field and assess the association of trial registration status (registered vs unregistered, prospectively registered vs retrospectively registered) with risk of bias, sufficient sample size, quality of reporting, and treatment effect estimates. Secondary objectives were to describe trial registration consistency with the final report and assess its association with risk of bias, sufficient sample size, and treatment effect estimates.

Study Design And Setting: A cross-sectional metaepidemiological study of trials included in a large Cochrane review on exercise treatments for CLBP.

Effectiveness of BNT162b2 COVID-19 primary series vaccination in children aged 5-17 years in the United States: a cohort study.

Background: COVID-19 vaccines are authorized for use in children in the United States; real-world assessment of vaccine effectiveness in children is needed. This study's objective was to estimate the effectiveness of receiving a complete primary series of monovalent BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine in US children.

Methods: This cohort study identified children aged 5-17 years vaccinated with BNT162b2 matched with unvaccinated children.

Incidence rates of thrombosis with thrombocytopenia syndrome (TTS) among adults in United States commercial and Medicare claims databases, 2017-2020.

Background: Increased risk of thrombosis with thrombocytopenia syndrome (TTS) following adenovirus vector-based COVID-19 vaccinations has been identified in passive surveillance systems. TTS incidence rates (IRs) in the United States (U.S.

Effectiveness of monovalent COVID-19 booster/additional vaccine doses in the United States.

Background: Monovalent booster/additional doses of COVID-19 vaccines were first authorized in August 2021 in the United States. We evaluated the real-world effectiveness of receipt of a monovalent booster/additional dose of COVID-19 vaccine compared with receiving a primary vaccine series without a booster/additional dose.

Methods: Cohorts of individuals receiving a COVID-19 booster/additional dose after receipt of a complete primary vaccine series were identified in 2 administrative insurance claims databases (Optum, CVS Health) supplemented with state immunization information system data between August 2021 and March 2022.