Publications by authors named "R Ogami"
Arrestins are known to be involved not only in the desensitization and internalization of G protein-coupled receptors but also in the G protein-independent activation of mitogen-activated protein (MAP) kinases, such as extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), to regulate cell proliferation and inflammation. Our previous study revealed that the histamine H receptor-mediated activation of ERK is dually regulated by G proteins and arrestins. In this study, we investigated the roles of G proteins and arrestins in the H receptor-mediated activation of JNK in Chinese hamster ovary (CHO) cells expressing wild-type (WT) human H receptors, the G protein-biased mutant S487TR, and the arrestin-biased mutant S487A.
View Article and Find Full Text PDFHere we report a case of sarcoidosis which demonstrated with bilateral ankle arthritis. We usually do not consider sarcoidosis routinely for the differential diagnosis of acute arthritis, however, up to 15 to 25% of sarcoidosis complicate arthritis, typically in ankle joints. Sarcoid arthritis is reported to occur mainly in young northern Europe women, whereas this case intimate that we should take sarcoidosis into account as the differential diagnosis of ankle arthralgia also among Asian men especially when combining upper respiratory symptoms.
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- G protein-coupled histamine H receptors are vital in allergic and inflammatory responses, influencing ERK phosphorylation which aids in producing inflammatory cytokines.
- This study investigates how ERK phosphorylation through H receptors is regulated differently by G proteins and arrestins, using specific mutant cells (S487TR and S487A) of human H receptors.
- Findings show that G protein-biased S487TR mediates quick ERK phosphorylation, while arrestin-biased S487A mediates a slower response, indicating distinct regulatory pathways for different phases of histamine-induced reactions.
Article Synopsis
- The study investigates a rare complication of carotid artery stenting (CAS), where patients experience prolonged neurological symptoms linked to fluid changes in the cerebrospinal fluid (CSF) space.
- Out of 19 patients who underwent 21 CAS procedures, 57.1% showed CSF space enhancement on imaging after the procedure, which was associated with factors like age, severity of stenosis, and acute procedural timing.
- The findings suggest that blood-brain barrier (BBB) disruption, leading to these complications, is more related to ischemic intolerance and reperfusion injury rather than sudden changes in blood flow, indicating that at-risk patients require careful monitoring to avoid serious repercussions.
This pilot study investigated the feasibility of Prolonged Exposure (PE) treatment for Japanese patients with posttraumatic stress disorder (PTSD) due to mixed traumatic events. Among 12 participants in this study, 9 women and 1 man completed between 9 and 15 weekly individual PE sessions; 2 female participants dropped out in early sessions. Among completers, the authors identified a significant reduction of symptom severity scores from pretreatment to posttreatment in terms of PTSD and depression on therapist-rated and self-rated measurements.
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