Publications by authors named "R Oeverink"
Trends in pharmacological management of paediatric patients with type 2 diabetes from 2000 to 2023 in German-speaking countries: Analysis based on the Diabetes Prospective Follow-up Registry.
Diabetes Obes Metab
December 2024
Background: Available basal insulin regimes differ in pharmacokinetic profiles, which may be related to subsequent changes in anthropometry in patients with type 1 diabetes. This analysis elucidates the standardized height and body mass index development (height and BMI standard deviation score [height-SDS and BMI-SDS]) in pediatric type 1 diabetes patients depending on the choice of basal insulin.
Methods: Longitudinal data of 10 338 German/Austrian patients from the Diabetes Prospective Follow-up (DPV, Diabetes Patienten Verlaufsdokumentation) database were analyzed.
Article Synopsis
- Autoimmune diseases, affecting about 8% of the population, have a notable link with Type 1 diabetes mellitus (T1DM), especially when combined with other autoimmune disorders like Hashimoto's thyroiditis and Addison's disease.
- A study analyzed data from the Prospective Diabetes Follow-up Registry to compare T1DM patients with these additional autoimmune diseases to those with isolated T1DM, focusing on demographics and clinical characteristics.
- Results showed that T1DM patients with other autoimmune diseases generally had longer diabetes duration, required higher insulin dosages, and experienced different rates of complications like neuropathy and microalbuminuria compared to isolated T1DM patients.
Neonatal screening for congenital primary hypothyroidism (CH) is mandatory in Germany but medical care thereafter remains inconsistent. Therefore, the registry HypoDok of the German Society of Pediatric Endocrinology and Diabetology (DGKED) was analyzed to evaluate the implementation of evidence-based guidelines and to assess the number of included patients. Inclusion criteria were (i) date of birth between 10/2001 and 05/2020 and (ii) increased thyroid-stimulating hormone (TSH) at screening and/or confirmation.
View Article and Find Full Text PDFBackground: The occurrence of antidrug antibodies is common in children treated with recombinant human growth hormone (rhGH). However, their clinical significance is unclear.
Objective: This study aimed to examine the clinical significance of anti-GH antibodies by analyzing the phenotype of patients who tested positive in relation to the quantity of anti-GH antibodies.