Publications by authors named "R O Weiss"
Purpose: Investigate the influence of baseline blood pressure (BP) on retinal nerve fiber layer (RNFL) rates of change (RoC) in glaucoma patients with central damage or moderate to severe disease.
Design: Prospective cohort study.
Participants: 110 eyes with ≥4 RNFL optical coherence tomography scans and ≥2 years of follow-up.
Article Synopsis
- Acute kidney injury (AKI) affects a significant number of critically ill patients, with the lack of standardized tools for implementing KDIGO criteria creating challenges for researchers.
- The pyAKI pipeline was developed to address these issues, using the MIMIC-IV database to establish a standardized model for consistent AKI diagnosis.
- Validation tests showed that pyAKI performs better than human annotations, achieving perfect accuracy and offering a valuable resource for clinicians and data scientists in AKI research.
Article Synopsis
- MPS IIIB is a rare disorder caused by defects in the enzyme NAGLU, leading to brain dysfunction due to the accumulation of heparan sulfate in lysosomes.
- Researchers created a Drosophila (fruit fly) model with various NAGLU mutations to study the disorder's effects on activity and sleep patterns, revealing significant hyperactivity and sleep issues.
- The study found that gene expression changes in mutant flies are linked to problems with nervous system development and synaptic function, suggesting that this fly model could help develop future therapies for MPS IIIB.
Emissions of HFC-23 do not reflect commitments made under the Kigali Amendment.
Commun Earth Environ
December 2024
HFC-23 (trifluoromethane) is a potent greenhouse gas released to the atmosphere primarily as a by-product of HCFC-22 (chlorodifluoromethane) synthesis. Since 2020, the Kigali Amendment to the Montreal Protocol has required Parties to destroy their HFC-23 emissions to the extent possible. Here, we present updated HFC-23 emissions estimated from atmospheric observations.
View Article and Find Full Text PDFImportance: Reliance on abstinence-based treatment success rules may fail to capture the full continuum of treatment response to buprenorphine plus medical counseling (BUP+MC) for opioid use disorder (OUD).
Objective: To describe patterns of reduction in illicit opioid use of patients both labeled as a success and nonsuccess based on an abstinent-based treatment outcome rule.
Design, Setting, And Participants: This study is a secondary data analysis of 4 harmonized randomized clinical trials on BUP+MC for OUD from multiple sites that included 869 patients with OUD.