Infant respiratory infections modulate lymphocyte homing to breast milk.

Introduction: Chemokines and their receptors are essential for leukocyte migration to several tissues, including human milk. Here, we evaluated the homing of T and B lymphocyte subsets to breast milk in response to ongoing respiratory infections in the nursing infant.

Methods: Blood and mature milk were collected from healthy mothers of nurslings with respiratory infections (Group I) and from healthy mothers of healthy nurslings (Group C).

Evaluation of SB-83, a 2-amino-thiophene derivative, against Leishmania species that cause visceral leishmaniasis.

Visceral leishmaniasis is a systemic disease that affects various internal organs and represents the most severe and fatal form of leishmaniasis. Conventional treatment presents significant challenges, such as prolonged management in hospital settings, high toxicity, and an increasing growing number of cases of resistance. In previous studies, our research group demonstrated the effective and selective activity of the 2-amino-thiophene derivative SB-83 in preclinical models of cutaneous leishmaniasis.

Tailoring a lignocellulosic biomass to simultaneously enhance N-doping and textural properties of porous carbons designed for effective environmental remediation.

Transforming lignocellulosic biomass waste into value-added materials like porous carbons offers a sustainable and increasingly important solution for its efficient management within a circular economy framework. Although the heteroatom-doping process enhances oxygen- or nitrogen-containing functionalities on porous carbons, it often leads to losses in structural integrity and other key functionalities. This study presents a novel protocol to produce N-doped porous carbons that efficiently introduces nitrogen groups while improving surface area, microporosity definition and the concentration of oxygen-containing functionalities.

An unexpected and tumultuous diagnosis of a left atrial mass.

This case presents a curious diagnosis in a young male presenting with chest pain. The first imaging tests suggested the presence of a hypovascular left atrial tumor. After cardiac magnetic resonance and the exclusion of extra-cardiac lesions, sarcoma emerged as the main diagnostic hypothesis.