The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence.

A key step in cytoplasmic mRNA degradation is the shortening of the poly(A) tail, which involves several deadenylase enzymes. Relatively little is known about the importance of these enzymes for the cellular physiology. Here we focused on the role of the highly similar Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the Ccr4-Not complex.

[Laser therapy in temporomandibular dysfunction (soft laser application points)].

It is work out and discuss one of the principal problems in the laser therapy use during the TMJ dysfunction treatment: the determination of the application points for the soft-laser stay, detailing the position of some of them that are essentials to obtain the objectives of this type of treatment.