Publications by authors named "R O Hickman"
Article Synopsis
- The study explored how self-rated physical and mental work demands affect cognition in older working adults, examining data from 6,377 participants in the 2004 Health and Retirement Study.
- Results indicated that higher physical demands correlated with poorer cognitive performance, while higher mental demands were linked to better cognition, but the relationship between the two demands was interconnected.
- The findings suggest that mental work demands may support cognitive health in older adults, especially when physical demands are low, highlighting the importance of considering interactions between different types of work demands in future research.
Background: Supporting the sleep health of surrogate decision-makers of patients in the intensive care unit is a research priority. However, few studies have approached sleep health as a multidimensional construct, instead focusing on 1 or 2 dimensions in isolation.
Objective: To holistically examine the sleep health (satisfaction, timing, efficiency, duration) of surrogate decision-makers of critically ill patients.
Human microglia play a pivotal role in neurological diseases, but we still have an incomplete understanding of microglial heterogeneity, which limits the development of targeted therapies directly modulating their state or function. Here, we use single-cell RNA sequencing to profile 215,680 live human microglia from 74 donors across diverse neurological diseases and CNS regions. We observe a central divide between oxidative and heterocyclic metabolism and identify microglial subsets associated with antigen presentation, motility and proliferation.
View Article and Find Full Text PDFThe aim of the study was to examine the psychometric properties of the Sickle Cell Self-efficacy Scale (SCSES) in an anonymous, online cohort of adults with sickle cell disease (SCD). The SCSES was completed by 60 adults with SCD. An exploratory factor analysis was conducted.
View Article and Find Full Text PDFIntroduction: Multiple individual sleep health dimensions (satisfaction, regularity, and duration) are associated with diabetes symptoms, precursors to micro-and macrovascular complications, among young adults with type 1 diabetes mellitus (T1DM). Nearly half of young adults with T1DM develop vascular complications; however, modifiable contributors of diabetes symptoms, including sleep health, have been understudied.
Methods: This cross-sectional quantitative descriptive study involved the completion of multiple validated self-report questionnaires and the collection of raw continuous glucose monitor and diary data over a 14-day period.