A Quantitative Analysis of Internal and External Loads in Aviation Firefighting Using a Simulated Scenario.

Background/objectives: Aviation firefighting is a strenuous occupation that requires individuals to engage in intense physical activity amidst elevated stress levels and extreme environmental conditions. Despite this, there has been limited investigation regarding the internal and external loads associated with aviation firefighting tasks, which include hose dragging, stair climbing, casualty evacuation, and fire extinguishing in airports and aircrafts. The aim of this study was to examine the internal and external loads placed on aviation firefighters.

Exploiting novel placental homing peptides for targeted drug delivery in breast Cancer.

More effective drug formulations are needed to increase the selectivity and efficacy of available chemotherapeutics. We have previously shown that nanoparticles decorated with the tumour homing peptide CGKRK can selectively deliver payloads to the placenta. In this study, we investigated whether two novel placental homing peptides NKGLRNK (NKG) and RSGVAKS (RSG) can be utilized to selectively deliver doxorubicin (DOX) to breast cancer cells.

Trajectories of intrinsic connectivity one year post pediatric mild traumatic brain injury: Neural injury superimposed on neurodevelopment.

The developing brain undergoes rapid changes throughout middle childhood and adolescence. The disambiguation of long-term changes in intrinsic activity following pediatric mild traumatic brain injury (pmTBI) from typical development can therefore only be ascertained in longitudinal studies with large sample size and at least three serial assessments. A comprehensive clinical battery and resting-state fMRI data were collected approximately 1-week (N = 263; 8-18 years old), 4-months (N = 192) and 1-year (N = 153) post-injury, with identical visits in a large cohort (N = 228) of age- and sex-matched healthy controls (HC).

Aging platelets shift their hemostatic properties to inflammatory functions.

Platelets are crucial players in hemostasis and thrombosis, but also contribute to immune regulation and host defense, using different receptors, signaling pathways and effector functions, respectively. Whether distinct subsets of platelets specialize in these diverse tasks is insufficiently understood. Here, we employed an in vivo pulse-labelling method in Mus musculus models for tracking in vivo platelet ageing and its functional implications.