[The protective activity of a new variant of the probiotic Acilact in exposure to ionizing radiation and anticancer chemotherapy under experimental conditions].

The aim of the study was to investigate the protective activity of a new variant of the probiotic Acilact in exposure to ionizing radiation and anticancer chemotherapy under experimental conditions. The study revealed protective effects of the preparation after combined exposure of mice to radiation and temperature. The preparation increased 30-day survival of the mice, inhibited intestinal colonization with gram-negative microorganisms, and increased resistance to LPS.

[The estimation of the nitric oxide role in the aggravation of combined radiation-thermal injuries].

The influence of specific inhibitor of inducible NO synthase S-ethil-isothiourea (as "Difetur" preparation) on liver NO production level, and 30-days survival, mean survival time and probability of mortality within animals under combined radiation/thermal injury (CRTI) were evaluated. Experiments were carrying out on mice (whole body gamma-irradiation at the dose of 7 Gy + 10% body surface full-thickness thermal burn). It was shown, that CRTI induce 2-fold statistical significant increase of NO production in liver of experimental animals.

[Some consequences of systemic inflammatory response in the pathogenesis of aggravation of outcomes of combined radiation and thermal injuries].

Experiments were executed on (CBA x C57BL6) F1 male mice. Animals were subjected to the total body irradiation with a dose 7 Gy or combine radiation-thermal injury (CRTI), when irradiated animals were additionally subjected to a thermal burn of 10% of the body surface. Some signs of systemic inflammatory response were investigated in these two compared groups.

[Susceptibility of irradiated animals to extremely dangerous pathogens (literature review)].

The review is dedicated to the susceptibility of irradiated animals anthrax, tularemia and other extremely dangerous infection diseases. Live vaccine strains application in irradiated animals and antibacterial drugs efficiency under conditions of combined effects of radiological and biological agents are reviewed. As a conclusion the list of unsolved research problems is proposed.

[Role of interleukin-6 (IL-6) in the pathogenesis of combined radiation/thermal injuries].

Combined injury such as whole body gamma-irradiation at the dose of 7 Gy+10% body surface full-thickness thermal burn were investigated in (CBA x C57BL6)F1 mice. Enhanced level of IL-6 in mice serum at 6-24 hs following combined injury was established. The potential inhibiting activity of pentoxifylline (POF) as an influence to IL-6 levels, and measure of several acute phase response signs has been evaluated.