Publications by authors named "R O Alarcon Parra"
Unlabelled: The antibody response to SARS-CoV-2 does not follow the immunoglobulin isotype pattern of primary responses, conflicting with the current interpretation of COVID-19.
Methods: Prospective cohort study of 191 SARS-CoV-2 infection cases and 44 controls from the second wave of COVID-19. The study stratified patients by severity and analyzed the trajectories of SARS-CoV-2 antibodies and multiple immune variables.
TRANSLATION, CROSS-CULTURAL ADAPTATION, AND VALIDATION OF THE IBD DISK FOR USE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES IN THE BRAZILIAN POPULATION.
Arq Gastroenterol
January 2025
Background: The inflammatory bowel disease (IBD) disk is a simple and quick method to assess the level of disability experienced by patients with IBD. It has been already translated and validated in European countries, however it was not yet translated and validated to use in Brazil.
Objective: This study was performed to translate and validate a Brazilian version of the IBD-Disk.
Article Synopsis
- Climate change is causing shifts in animal habitats, particularly affecting the distribution of threatened marine species like whale sharks.
- Projections indicate that by 2100, whale sharks could lose more than 50% of their core habitat in some areas, with significant geographic shifts that could place them in closer proximity to large ships.
- The increase in whale shark interaction with shipping is expected to be dramatically higher under high emission scenarios compared to sustainable development, highlighting the urgency for better climate-threat predictions in conservation strategies for endangered marine life.
Article Synopsis
- - Chromothripsis is a process where a single catastrophic event causes significant genomic rearrangements, but its variability across different tumor clones and response to treatments is not well understood.
- - This study investigates chromothripsis in p53-deficient medulloblastoma and neural stem cells, focusing on the genomic and transcriptomic changes involved.
- - The researchers analyze the order of genetic events, explore subclonal variation, and identify how chromothripsis influences cancer development, targeted therapies, and the fitness of neural progenitor cells.