Ethnic Manifestations of Gene Polymorphisms of Vitamin D Receptor (VDR) in Adolescents of Western Kazakhstan Region.

Background (objectives): The objective of the article is studying the connection of VDR gene polymorphisms with bone tissue mineral density and biochemical marker of 25-PO vitamin D in adolescents of both ethnic groups, living in Western Kazakhstan Region.

Methods: The study included 110 relatively healthy children aged 13-18 years of Aktobe, the representatives of Kazakh ethnic group e 66 (Kazakh children) and Slavonic e 44 (Russian children). The groups were formed according to BTMD data, ethnic affiliation and according to content of vitamin D and gene polymorphism of vitamin D (VDR).

[FEATURES BONE METABOLISM IN ADOLESCENTS LIVING IN KAZAKHSTAN (ON THE EXAMPLE AKTOBE)].

The purpose of this work is to study by densitometry the bone mineral density (BMD) in Kazakhstan adolescents of Aktobe and biological markers of the bone metabolism. By obtained data revealed the presence of osteopenia among apparently healthy Kazakhstan adolescents in 72% of cases. Indicators of bone mineral density in adolescents two ethnic groups (Kazakhs and Russian) were unremarkable.