Publications by authors named "R Nosalski"
Inflammatory responses in small vessels play an important role in the development of cardiovascular diseases, including hypertension, stroke, and small vessel disease. This involves various complex molecular processes including oxidative stress, inflammasome activation, immune-mediated responses, and protein misfolding, which together contribute to microvascular damage. In addition, epigenetic factors, including DNA methylation, histone modifications, and microRNAs influence vascular inflammation and injury.
View Article and Find Full Text PDFHypertension is a global health problem, with >1.3 billion individuals with high blood pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension, emphasizing the crucial roles of immune cells, cytokines and chemokines in disease initiation and progression.
View Article and Find Full Text PDFThe importance of microvascular inflammation in ageing and age-related diseases: a position paper from the ESH working group on small arteries, section of microvascular inflammation.
J Hypertens
October 2023
Article Synopsis
- Microcirculation plays a crucial role in regulating organ function and is significantly affected by environmental stressors, leading to aging and related diseases.
- Dysfunction in microvascular systems can accumulate health issues and increase the risk of cardiovascular problems, largely due to microvascular inflammation.
- The paper emphasizes the need for more research to identify specific molecular targets for early intervention in chronic age-related diseases, highlighting the importance of understanding microvascular inflammation in contemporary healthcare.