Publications by authors named "R Nishida"
Cancer sarcopenia is highly prevalent in patients with advanced cancer, which is closely related to the disease prognosis. Overcoming cancer sarcopenia is important for cancer treatment. Cystine and theanine (CT), antioxidant amino acids, have been applied to the nutritional intervention of various diseases but their effects remain unclear on cancer sarcopenia.
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- - Low-intensity pulsed ultrasound (LIPUS) and transcutaneous carbon monoxide (CO) therapy were tested in rats to determine if their combined use would enhance fracture healing more effectively than using either treatment alone.
- - The study created femoral shaft fractures in rats and divided them into four groups: combination (LIPUS + CO), LIPUS only, CO only, and a control group, treating them regularly for four weeks and assessing bone healing through various methods.
- - Results showed that the combination group had significantly better fracture healing scores, higher vascular density, and increased gene expression related to bone growth compared to the control and single therapy groups at multiple time points throughout the study.
Rodents have a strong motivation for wheel running; however, the neural mechanisms that regulate their motivation remain unknown. We investigated the possible involvement of serotonin (5-HT) systems in regulating motivation for wheel running in male mice. Systemic administration of a 5-HT receptor antagonist (WAY100635) increased the number of wheel rotations, whereas administration of a 5-HT or 5-HT receptor antagonist (volinanserin or SB242084, respectively) decreased it.
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- Transcutaneous CO application was shown to enhance muscle fiber-type switching, fracture healing, and bone growth by increasing blood flow and new blood vessel formation.
- In a rat study, transcutaneous CO treatment prevented muscle atrophy and bone loss that typically occur with inactivity, as seen in the hindlimb suspension model.
- Results indicated that rats treated with CO had larger muscle fibers, healthier bone structure, and better expression of markers related to muscle and bone growth compared to those not receiving the treatment.
The interconnected structures in a 3D scaffold allows the movement of cells and nutrients. Therefore, this study aimed to investigate the in-vivo bioactivity of 3D-printed β-tricalcium phosphate (β-TCP) and hydroxyapatite (HAP) scaffolds that replicate biological bone. This study included 24-week-old male New Zealand white rabbits.
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