Publications by authors named "R Nisha"
Article Synopsis
- Prolonged wound healing is a major clinical issue, and this research explores nanotechnology, specifically nanofiber (NF) scaffolds, as a potential solution.
- The study developed multifunctional AZL-CS/PVA-NF scaffolds enriched with azilsartan medoxomil, showing a drug release rate of around 93.86% and good antimicrobial properties against common bacteria like Staphylococcus aureus.
- In vivo results indicated that these scaffolds enhance tissue regeneration and reduce inflammation in a rat model, highlighting their promise as innovative drug carriers for improving wound care.
Article Synopsis
- Targeted therapies improve tumor screening and treatment while reducing side effects, particularly in cancers like liver cancer that have high folate receptor expression.
- This study focused on creating bosutinib cubosomes modified with folic acid (BSTMF) to enhance anticancer effects against hepatocellular carcinoma through specific biological pathways.
- BSTMF showed promising results in cell viability tests, delivering drugs efficiently to tumor tissues and indicating improved therapeutic outcomes compared to existing treatments.
Article Synopsis
- Researchers developed a new type of nanoparticle, CE-IHP@Tr*Pe-Ch-NPs, designed specifically to improve drug delivery to colon cancer cells by utilizing l-Carnitine modification for better uptake.
- These nanoparticles demonstrated a suitable size and charge, while showing good compatibility with certain cell lines (J774.2) and effectively reducing cell viability in colon (DLD-1, HT-29) and breast (MCF7) cancer cells.
- The studies indicated that these nanoparticles have strong targeting potential and may serve as an effective approach for treating colorectal cancer.
Infected wounds that do not heal are a worldwide problem that is worsening, with more people dying and more money being spent on care. For any disease to be managed effectively, its root cause must be addressed. Effective wound care becomes a bigger problem when various traditional wound healing methods and products may not only fail to promote good healing.
View Article and Find Full Text PDFStem rust is one of the major diseases threatening wheat production globally. To identify novel resistance quantitative trait loci (QTLs), we performed 35K Axiom Array SNP genotyping assays on an association mapping panel of 400 germplasm accessions, including Indian landraces, in conjunction with phenotyping for stem rust at seedling and adult plant stages. Association analyses using three genome wide association study (GWAS) models (CMLM, MLMM, and FarmCPU) revealed 20 reliable QTLs for seedling and adult plant resistance.
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