Publications by authors named "R Nirel"
Ataxia-telangiectasia (A-T) is an autosomal-recessive disorder caused by pathogenic variants (PVs) of the ATM gene, predisposing children to hematological malignancies. We investigated their characteristics and outcomes to generate data-based treatment recommendations. In this multinational, observational study we report 202 patients aged ≤25 years with A-T and hematological malignancies from 25 countries.
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- - A systematic review of global studies examined how exposure to fine particulate matter (PM) during pregnancy affects birth weight, finding substantial inconsistencies and unexplained variability among research results.
- - Out of 2,677 articles, 84 met the criteria for detailed analysis, indicating a stronger link between low birth weight (LBW) and PM exposure, particularly in Europe compared to Asia and the US.
- - The study concludes that factors like geographical region contribute to the varying impact of PM on birth weight, suggesting that local data should inform policies rather than relying on combined summary statistics.
Children with hemato-oncological diseases or following stem cell transplantation (SCT) are at high risk for life-threatening infections; sepsis in this population constitutes a substantial proportion of pediatric intensive care unit (PICU) admissions. The current pediatric prognostic scoring tools to evaluate illness severity and mortality risk are designed for the general pediatric population and may not be adequate for this vulnerable subpopulation. Retrospective analysis was performed on all PICU admissions for sepsis in children with hemato-oncological diseases or post-SCT, in a single tertiary pediatric hospital between 2008 and 2021 ( = 233).
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- * It found that both low and high levels of PM exposure are associated with higher risks of PTB compared to moderate exposure levels, with hazard ratios indicating increased risk.
- * Additionally, ambient temperature played a significant role, where low temperatures increased risks for PM exposure, but high temperatures showed a reversed trend, highlighting the importance of considering climate factors in understanding the risk of PTB due to PM exposure.
Studies have suggested an association between particulate matter (PM) air pollution and certain congenital anomalies (CAs). However, most studies assumed a linear concentration-response relation and were based on anomalies that were ascertained at birth or up to 1 year of age. We investigated associations between exposures to PM during the first trimester of pregnancy and CAs in 9 organ systems using birth and childhood follow-up data from a leading health care provider in Israel.
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