Mucuna beans administered through hydrogen-infused superheated steam in advanced Parkinson's disease.

This retrospective review on patients with Parkinson's disease, focusing on using mucuna beans (MB), its dosing, and administration methods. Two hundred patients taking 1-3 g of MP dissolved in hot water daily orally. Besides, MB administration via enema may be viable, especially when oral L-dopa efficacy is insufficient.

Influence of current and previous smoking on current phenotype in Parkinson's disease.

Introduction: Although an inverse correlation between smoking and Parkinson's disease (PD) has been reported, research into the effect of smoking on current clinical progression remains limited for PD patients. Elucidation of a specific PD population who would benefit from smoking is challenging.

Methods: We evaluated 110 consecutive PD patients (mean age; 71.

Establishing diagnostic criteria for Perry syndrome.

Objective: To establish international diagnostic criteria for Perry syndrome, a disorder characterised by clinical signs of parkinsonism, depression/apathy, weight loss, respiratory symptoms, mutations in the gene and TAR DNA-binding protein 43 (TDP-43) pathology.

Methods: Data from the published literature and newly identified patients were gathered and analysed during and after the International Symposium on Perry syndrome in Tokyo to identify diagnostic criteria for Perry syndrome.

Results: Eighty-seven patients with Perry syndrome carrying mutations from 20 families were included in this study, and common signs of the disorder were identified, including parkinsonism (95.

Communication aid device utilizing event-related potentials for patients with severe motor impairment.

The purpose of the present study was to develop a communication aid device utilizing event-related potentials (ERPs) for patients with severe motor disabilities. Preliminary experiments were performed on eight healthy volunteers to determine the optimal methods of presentation of visual stimuli and an off-line analysis of electroencephalography signals. Three clinical experiments were performed online on 17 healthy volunteers, 5 patients with amyotrophic lateral sclerosis, and 1 patient with olivopontocerebellar atrophy.