Publications by authors named "R Neale"
Article Synopsis
- A study investigated the link between skin screening/surveillance and increased melanoma diagnoses using data from over 10 million Australians over several years.* -
- The results showed that individuals who were screened or surveilled had significantly higher rates of skin biopsies, excisions for suspected melanoma, and confirmed melanoma compared to those who weren't.* -
- Findings suggest that increased skin detection activities can lead to higher levels of diagnostic events and melanoma incidence, indicating a robust correlation between screening practices and skin cancer outcomes.*
Article Synopsis
- The study investigated the link between 25-hydroxy vitamin D (25(OH)D) levels and the risk and progression of abdominal aortic aneurysm (AAA).
- Researchers recruited 4,673 participants, finding that higher 25(OH)D levels were associated with a reduced likelihood of being diagnosed with AAA, with a significant decrease in odds noted in both Queensland and Western Australia.
- However, among participants with small AAA, those with higher vitamin D levels experienced faster AAA growth, suggesting a paradox where high vitamin D is linked to both lower diagnosis rates and quicker aneurysm expansion, warranting further investigation.
Article Synopsis
- The study aimed to estimate melanoma incidence in Australia based on ancestry risk factors from 2006 to 2021, breaking down the data by sex and age groups.
- The research utilized melanoma incidence rates from the U.S. SEER database alongside Australian census data to model and analyze trends in melanoma rates by ancestry-based risk.
- Results indicated a decline in the proportion of high-risk ancestry individuals and a decrease in melanoma rates among younger age groups, likely due to reduced ultraviolet radiation exposure attributed to social and behavioral changes.
Background: Although there is evidence of a link between vitamin D status and risk of multiple sclerosis (MS), there has been no systematic review where the exposure measure was vitamin D deficiency rather than 25 hydroxy vitamin D (25(OH)D) concentration. We conducted an updated systematic review and meta-analysis to estimate the association between vitamin D deficiency, defined in most studies as a serum 25(OH)D concentration of < 50 nmol L, and MS.
Methods: We searched the MEDLINE, EMBASE, and CINAHL databases to identify relevant publications.
Importance: It is unknown whether germline genetic factors influence in situ melanoma risk differently than invasive melanoma risk.
Objective: To determine whether differences in risk of in situ melanoma and invasive melanoma are heritable.
Design, Setting, And Participants: Three genome-wide association study meta-analyses were conducted of in situ melanoma vs controls, invasive melanoma vs controls, and in situ vs invasive melanoma (case-case) using 4 population-based genetic cohorts: the UK Biobank, the FinnGen cohort, the QSkin Sun and Health Study, and the Queensland Study of Melanoma: Environmental and Genetic Associations (Q-MEGA).