Publications by authors named "R Nathani"
Patients with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) primary breast cancer (BC) have low pathological complete response (pCR) rates with neoadjuvant chemotherapy. A subset of ER+/HER2- BC contains dense lymphocytic infiltration. We hypothesized that addition of an anti-programmed death 1 agent may increase pCR rates in this BC subtype.
View Article and Find Full Text PDFObjectives: The impact of mild autonomous cortisol secretion (MACS) on cognition is incompletely characterized. We aimed to assess cognition in patients with MACS, identify factors associated with lower cognition, and determine the impact of adrenalectomy on cognition.
Methods: We conducted a cross-sectional study (4/2019 to 10/2022) and a longitudinal cohort study (10/2021 to 9/2023) of adults with MACS and referent subjects.
Article Synopsis
- Research on peripheral artery disease (PAD) is hindered by the absence of a national registry and insufficient diagnostic coding in electronic health records.
- A new natural language processing (NLP) system helped establish a registry of over 103,000 new PAD patients within the Veterans Health Administration, revealing high rates of comorbidities and significant clinical outcomes over a year.
- The study found notable one-year mortality (9.4%) and incidences of cardiovascular (5.6 per 100 patient-years) and limb events (4.5 per 100 patient-years), highlighting the urgent need for better care strategies for this high-risk population.
Background: Severe alcohol-associated hepatitis (AH) that is nonresponsive to corticosteroids is associated with high mortality, particularly with concomitant acute-on-chronic liver failure (ACLF). Most patients will not be candidates for liver transplantation (LT) and their outcomes are largely unknown. Our aim was to determine the outcomes of these declined candidates and to derive practical prediction models for transplant-free survival applicable at the time of the waitlist decision.
View Article and Find Full Text PDFContext: Mild autonomous cortisol secretion (MACS) is diagnosed based on postdexamethasone cortisol >1.8 µg/dL. Scarce evidence exists on steroid circadian secretion and steroid metabolome in MACS.
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