Publications by authors named "R Nagrani"
Article Synopsis
- The study explored how vitamin D levels affect inflammation markers in children and teens across eight European countries.
- Researchers found that higher vitamin D levels were linked to increased levels of adiponectin and reduced inflammation scores, particularly in children with normal weight.
- In overweight or obese children, only a positive connection to one marker (IP-10) was seen, highlighting the need for weight management to see improvements in inflammation related to vitamin D.
Introduction: Despite international efforts, the number of individuals struggling with obesity is still increasing. An important aspect of obesity prevention relates to identifying individuals at risk at early stage, allowing for timely risk stratification and initiation of countermeasures. However, obesity is complex and multifactorial by nature, and one isolated (bio)marker is unlikely to enable an optimal risk stratification and prognosis for the individual; rather, a combined set is required.
View Article and Find Full Text PDFAims/hypothesis: There is increasing evidence for the existence of shared genetic predictors of metabolic traits and neurodegenerative disease. We previously observed a U-shaped association between fasting insulin in middle-aged women and dementia up to 34 years later. In the present study, we performed genome-wide association (GWA) analyses for fasting serum insulin in European children with a focus on variants associated with the tails of the insulin distribution.
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- This study investigates the relationship between vitamin D status and cardiometabolic risk markers in children, particularly focusing on those with obesity compared to healthy-weight children.
- The research involved 2,171 children from the IDEFICS/I.Family cohort, analyzing how serum vitamin D levels correlate with various health indicators like blood pressure, triglycerides, and insulin resistance.
- The findings suggest that lower vitamin D levels are linked to worse cardiometabolic outcomes, indicating that improving vitamin D status early in life could help lower these health risks in children.
The effects of exposure to black carbon (BC) on various diseases remains unclear, one reason being potential exposure misclassification following modelling of ambient air pollution levels. Urinary BC particles may be a more precise measure to analyze the health effects of BC. We aimed to assess the risk of prediabetes and metabolic syndrome (MetS) in relation to urinary BC particles and ambient BC and to compare their associations in 5453 children from IDEFICS/I.
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