Publications by authors named "R NICOLAI"
Objective: to investigate the trend of autoantibody titers during a 2-year follow-up in pediatric systemic lupus erythematosus (pSLE) and pediatric Sjögren's syndrome (pSS).
Methods: Autoantibodies testing was performed every 3-4 months during 2 years from disease onset in a cohort of children with pSLE and pSS.
Results: We enrolled 21 children with pSLE and 22 children with pSS.
Objectives: Methotrexate (MTX) is the most used drug to treat children and adults with arthritis and its use is burdened by adverse effects. The MTX intolerance severity score (MISS) was developed in English to identify patients who are intolerant to MTX. The aim of this study was to translate and validate the MISS in Italian.
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- The study focuses on the safety and effectiveness of CD19-targeting CAR T cells in a 12-year-old boy with resistant juvenile dermatomyositis (JDM).
- The patient underwent a single CAR T cell infusion after intensive lymphodepletion and showed significant immune response with complete B cell depletion and a mild side effect profile.
- Remarkably, he experienced sustained clinical improvements over eight months post-infusion without needing ongoing immunosuppressive therapy.
Objectives: Paediatric Sjögren's syndrome (pSS) is a rare chronic autoimmune disorder, characterised by inflammation of exocrine glands. B cell hyperactivation plays a central role in adult-onset Sjogren. This study was designed to analyse B cell and T cell phenotype, levels of BAFF, and selection of autoreactive B cells in patients with pSS.
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