Publications by authors named "R N ROBERTSON"
Spreading depolarization (SD) temporarily shuts down neural processing in mammals and insects. Age is a critical factor for predicting the consequences of SD in humans. We investigated the effect of aging in an insect model of SD and explored the contribution of oxidative stress.
View Article and Find Full Text PDFImpact of Smokeless Oral Nicotine Products on Cardiovascular Disease: Implications for Policy, Prevention, and Treatment: A Policy Statement From the American Heart Association.
Cheryl R Dennison Himmelfarb Neal L Benowitz Melissa D Blank Aruni Bhatnagar Paul J Chase Rose Marie Robertson
Circulation
January 2025
Article Synopsis
- Smokeless oral nicotine products are addictive and can negatively impact cardiovascular health, particularly in individuals with pre-existing heart or cerebrovascular conditions, and can also increase the risk of oral cancer depending on their chemical composition.
- The market for these products has rapidly expanded since the last American Heart Association policy, particularly with the rise of tobacco-free oral nicotine pouches, but their health effects remain unstudied.
- There is a need for strong public policies to help end tobacco addiction, focusing on preventing initiation and promoting cessation through established treatment options.
Duchenne muscular dystrophy (DMD) is a lethal disease caused by mutations in the gene that encodes dystrophin. Dystrophin deficiency also impacts muscle stem cells (MuSCs), resulting in impaired asymmetric stem cell division and myogenic commitment. Using MuSCs from DMD patients and the DMD mouse model , we found that PTPN1 phosphatase expression is up-regulated and STAT3 phosphorylation is concomitantly down-regulated in DMD MuSCs.
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