Publications by authors named "R N Naga Santhosh Irrinki"
Purpose: A monoclonal antibody, trastuzumab, is used for immunotherapy for HER2-expressing breast cancers. Large-sized antibodies demonstrate hepatobiliary clearance and slower pharmacokinetics. A trastuzumab fragment (Fab; 45 kDa) has been generated for theranostic use.
View Article and Find Full Text PDFNipple discharge is the third most common breast related complaint seen in the breast clinics. Although the majority of cases are due to a benign etiology, 5%-12% cases of pathological nipple discharge may be harboring an underlying malignancy. A thorough radiological workup in cases of pathological nipple discharge is thus of utmost importance, with the initial imaging modality depending on the age of the patient.
View Article and Find Full Text PDFArticle Synopsis
- Gastrointestinal stromal tumors (GIST) are the most frequent type of mesenchymal tumors, with anemia being a common issue among affected patients, yet the link between tumor size and anemia severity is unclear.
- A study involving 20 GIST patients who had surgical resections aimed to analyze the relationship between anemia and various factors, particularly tumor volume, gathering data on demographics, clinical presentations, and tumor characteristics.
- Results indicated no significant relationship between tumor volume and hemoglobin levels, suggesting further research with larger patient groups is necessary to confirm these findings.
Background: Placement of ventriculoperitoneal shunt is a standard treatment for hydrocephalus. The risk of shunt malfunction in the first year is 25%-40% making endoscopic third ventriculostomy (ETV) a feasible option in those patients with shunt failure.
Aim: The aim of this study was to evaluate ETV as a viable option in patients with shunt malfunction and to correlate the clinical outcome following successful ETV with functional and radiological outcomes.