Publications by authors named "R N Maniar"
A major paradigm shift in the diagnosis, management, and survival outcomes of early and advanced non-small cell lung cancer has transpired over the past few decades in thoracic oncology with the incorporation of molecular testing, targeted therapy, immunotherapy, neoadjuvant, and adjuvant approaches. However, transformation in the management and survival outcomes of rare lung tumors is lacking. Given the scarcity of these tumor types, randomized trials are rarely performed, and treatment is extrapolated from case series, tumor-agnostic trials, or cancers with similar histology.
View Article and Find Full Text PDFDespite 30 years as a public health emergency, tuberculosis (TB) remains one of the world's deadliest diseases. Most deaths are among persons with TB who are not reached with diagnosis and treatment. Thus, timely screening and accurate detection of TB, particularly using sensitive tools such as chest radiography, is crucial for reducing the global burden of this disease.
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- The text discusses the relationship between vertical ionization energies from bound electronic systems in their ground state and Kohn-Sham orbital energies in DFT, confirming that this relationship holds true for the lowest ionization energy.
- It highlights recent comparisons of experimental photoemission thresholds in various copper oxide (CuO) molecules against predicted orbital energies using different DFT methods, revealing significant discrepancies.
- The study expands the analysis to include various DFT approximations, noting that while some methods show promising accuracy, none successfully match the experimental data for the copper oxide anions in question.
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- Pakistan has one of the highest rates of tuberculosis (TB) in the world, and a study was conducted to assess the prevalence of TB in adults and the risk of M. tuberculosis infection in children in Karachi, focusing on areas with and without prior active case-finding (ACF) activities.
- The research involved surveys between March 2018 and May 2019, with almost 35,000 adults and over 1,500 children participating, revealing a higher prevalence of TB in areas with no prior ACF (421 cases per 100,000) compared to areas with prior ACF (279 cases per 100,000).
- The findings indicated that ACF efforts in Korangi district likely reduced TB prevalence and transmission,
Density functional approximations to the exchange-correlation energy can often identify strongly correlated systems and estimate their energetics through energy-minimizing symmetry-breaking. In particular, the binding energy curve of the strongly correlated chromium dimer is described qualitatively by the local spin density approximation (LSDA) and almost quantitatively by the Perdew-Burke-Ernzerhof generalized gradient approximation (PBE-GGA), where the symmetry breaking is antiferromagnetic for both. Here, we show that a full Perdew-Zunger self-interaction-correction (SIC) to LSDA seems to go too far by creating an unphysical symmetry-broken state, with effectively zero magnetic moment but non-zero spin density on each atom, which lies ∼4 eV below the antiferromagnetic solution.
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