Chronic fluoxetine upregulates activity, protein and mRNA levels of cytosolic phospholipase A in rat frontal cortex.

This corrects the article DOI: 10.1038/sj.tpj.

Retraction Note: n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism.

This article has been retracted by the editor because an investigation by the National Institutes of Health concluded that the data represented by Figures 2a-c and 3e and Figure 4a were falsified. JT Arnold, SI Rapoport, RN Ertley, and RP Bazinet agree with this retraction. JS Rao and H-J Lee could not be reached for comment.

Chronic administration of lamotrigine downregulates COX-2 mRNA and protein in rat frontal cortex.

Chronic administration to rats of mood-stabilizers that are effective against mania in bipolar disorder, is reported to downregulate markers of the brain arachidonic acid cascade. We hypothesized that chronic administration of lamotrigine, which is used to treat depression and rapid cycling in bipolar disorder, might do so as well. Male CDF rats were administered a therapeutically relevant dose of lamotrigine (10 mg/kg) or vehicle intragastrically once daily for 42 days.

Chronic NMDA administration to rats up-regulates frontal cortex cytosolic phospholipase A2 and its transcription factor, activator protein-2.

Excessive N-methyl-D-aspartate (NMDA) signaling is thought to contribute to bipolar disorder symptoms. Lithium and carbamazepine, effective against bipolar mania, are reported in rats to reduce brain transcription of an arachidonic acid selective calcium-dependent cytosolic phospholipase A(2) (cPLA(2)), as well as expression of one of its transcription factors, activator protein (AP)-2. In this study, we determined if chronic administration of NMDA (25 mg/kg i.