MICRORNAS AS ULTRAVIOLET IRRADIATION EFFECTS REGULATORS IN SKIN CELLS.

MicroRNAs belong to small non-coding RNA which regulate gene expression via mRNA degradation or translation inhibition. MicroRNAs are active modulators of gene expression in the skin caused by exogenous factors including ultraviolet irradiation. These effects are realized by targeting transcription factors and signaling systems components.

[Characteristics of CD99 expression in the skin of psoriasis patients].

The pattern of CD99 expression in the skin was studied in 22 patients with disseminated psoriasis. The patients' skin biopsy specimens were immunohistochemically stained by the standard procedure using monoclonal antibodies to CD99. The progression of psoriasis was characterized by the increased expression of the protein in the dermis (lymphocytes and vascular endothelium) and epidermis (keratinocytes) with the antigen being located not only in the cytoplasm, but also in the membrane.

Interaction between single nucleotide polymorphism in catalase gene and catalase activity under the conditions of oxidative stress.

Catalase is an antioxidant enzyme the activity of which is crucial for the protection against damage caused by reactive oxygen species. The -262C>T polymorphism in the promoter region of catalase gene was found to be associated with altered catalase levels. In this study, peripheral blood mononuclear cells catalase activity was measured after H(2)O(2)-induced oxidative stress.

Changes in the content of protein and lipid oxidative modification products in tumor tissue at different stages of lung cancer.

The content of LPO products (conjugated dienes, MDA) and products of oxidative modification of proteins (protein carbonyl derivatives) is reduced in tumor tissue in comparison with normal tissue and varies depending on the disease stage.