Everything but the Kitchen Sink: A Mixed Methods Approach to Health IT Usability Testing.

Usability testing has become a necessary step to successfully implement health information technology, but despite the expanded variety of usability methods, systems still are not guaranteed to meet user needs in a hectic and dynamic healthcare environment. The present work discusses some of the metrics employed with the intent of usability testing clinical decision support alerts for the early identification of sepsis patients. By utilizing methods such as eye tracking, think aloud protocols, human computer interaction, and more, health information technology can be adequately developed to ensure effective, efficacious, and optimal integration.

Aerodigestoscopy (ADS): The Feasibility, Safety, and Comfort of a Comprehensive Procedure for the Evaluation of Physiological Disorders of the Aerodigestive Tract.

Limited access to the comprehensive assessment of disorders of the upper aerodigestive tract is a barrier to care in rural health facilities. Assessment of the full aerodigestive tract requires a variety of specialists. The inability to access the necessary specialists can result in misdiagnosis, underdiagnosis, and increased associated mortality.

Trace organic compounds and photosensitizing activity in Salvadoran surface and tap water sources: A first look.

Despite their potential risks to human health and the environment at ng/L to μg/L concentrations, there has been relatively little effort to measure trace organic compounds (TOrCs) in surface waters of Central America. The concentrations of eighteen TOrCs detected at eleven surface water sites in the Lempa River basin of El Salvador and four sources of drinking water for the cities of San Salvador, Antiguo Cuscatlán, Soyapango, and Santa Tecla are reported here. All samples were analyzed via liquid chromatography with tandem mass spectrometry (LC-MS/MS).

PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cells.

Breast cancer stem cells (BCSCs) are a rare cell population that is responsible for tumour initiation, metastasis and chemoresistance. Despite this, the mechanism by which BCSCs withstand genotoxic stress is largely unknown. Here, we uncover a pivotal role for the arginine methyltransferase PRMT5 in mediating BCSC chemoresistance by modulating DNA repair efficiency.