Publications by authors named "R N Amrutha"
Article Synopsis
- The matrix metalloproteinases (MMPs) are zinc proteases that help break down components of the extracellular matrix (ECM) and are involved in processes like inflammation and cell growth.
- A study of Drosophila MMPs Mmp1 and Mmp2 shows that while they are important for tissue remodeling, they are not necessary for embryonic development, and their localization (either membrane-anchored or released) is key in distinguishing their roles.
- MMPs are categorized into secretory and membrane types based on their structure and function, and while humans have many MMPs, Drosophila only has two, highlighting the potential complexity of MMP regulation in disease progression.
Periodontitis and oral squamous cell carcinoma (OSCC) are prevalent oral diseases with distinct etiologies, yet they share certain molecular and biological characteristics. Gene expression datasets from the gene expression omnibus (GEO) repository (GSE30784 for OSCC and GSE10334 for periodontitis) were analyzed. Data preprocessing and differential gene expression analysis using GEO2R identified common differentially expressed genes (DEGs), and FunRich software facilitated the construction of a protein-protein interaction (PPI) network on the STRING database.
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- Heat shock proteins (HSPs), particularly HSP70, are linked to tumor growth and immune evasion in various cancers, and this study aimed to assess HSP70 as a potential predictor of malignant transformation in oral epithelial dysplasia.* -
- The research involved analyzing 60 tissue samples, including different grades of dysplasia and normal tissues, for HSP70 expression through immunohistochemistry and statistical methods.* -
- Results indicated that HSP70 expression increases with the severity of dysplasia and is significantly higher in established carcinoma, suggesting HSP70 may have prognostic value, although further studies with larger sample sizes are necessary for validation.*
Purpose: These days laparoscopic inguinal hernia surgery, both totally extraperitoneal (TEP) and transabdominal preperitoneal (TAPP), is a commonly performed procedure due to advancements in laparoscopic instruments and the availability of skilled laparoscopic surgeons. The purpose of this study was to compare the perioperative complications of these two procedures.
Methods: This was a prospective observational study between July 2019 and December 2020.
Aim: The purpose of the current study was to investigate the presence of the ponticulus posticus (PP) frequently encountered in lateral cephalograms.
Materials And Methods: About 500 patients of age 12-40 years were selected whose digital lateral cephalogram was recorded and traced to confirm the presence of the PP and categorize as: (A) Absent, as evidenced by lateral cephalograms. (B) Complete PP evidenced by the presence of circumferential bone bridge that connected the upper articular process to the atlas's posterior arch.