An appraisal of blood-cerebrospinal fluid barrier dysfunction during the course of Guillain Barré syndrome.

Background: Elevated cerebrospinal fluid (CSF) total protein (TP) concentration (mainly due to a dysfunctional blood-CSF barrier (B-CSFB)) with normal cell count is a hallmark for the diagnosis of Guillain-Barriota syndrome (GBS).

Aims: This work presents the evaluation of B-CSFB dysfunction with respect to the course, severity, and clinical features of GBS.

Materials And Methods: A sample of CSF was collected on admission from 68 patients of both genders (15 children and 53 adults) diagnosed with GBS.