Publications by authors named "R Mussat Sartor"
Emerging evidence suggests a significant role of gut microbiome in bone health. Aging is well recognized as a crucial factor influencing the gut microbiome. In this study, we investigated whether age-dependent microbial change contributes to age-related bone loss in CB6F1 mice.
View Article and Find Full Text PDFEarly subclinical stages of the inflammatory bowel diseases: insights from human and animal studies.
Am J Physiol Gastrointest Liver Physiol
January 2025
The inflammatory bowel diseases (IBD) occur in genetically susceptible individuals that mount inappropriate immune responses to their microbiota leading to chronic intestinal inflammation. The natural history of IBD progression begins with early subclinical stages of disease that occur before clinical diagnosis. Improved understanding of those early subclinical stages could lead to new or improved strategies for IBD diagnosis, prognostication, or prevention.
View Article and Find Full Text PDFMicrobiome modification for personalized treatment of dysbiotic diseases.
Cell Host Microbe
August 2024
Fecal microbial transplantation (FMT) for inflammatory diseases or refractory immune checkpoint inhibitor therapy is less effective than for preventing recurrent Clostridioides difficile infection. This commentary outlines strategies to use biomarkers of successful FMT to guide newer approaches to restore microbial homeostasis in individuals with dysbiosis-mediated inflammation.
View Article and Find Full Text PDFArticle Synopsis
- - Mitochondrial dysfunction in inflammatory bowel disease (IBD) leads to increased oxygen levels in the gut, fostering the growth of certain bacteria and disrupting the balance of the microbiome, which can harm metabolism and immunity.
- - A novel compound called AuPhos enhances mitochondrial function in intestinal cells, reduces colitis symptoms, and restores a healthy gut microbiome in mice models, implying its potential benefits for IBD patients.
- - The study utilized various experimental methods, including animal models and human tissue analyses, showing that AuPhos alters microbial composition and improves oxygen use in gut cells, indicating its role in correcting IBD-related metabolic issues.
Article Synopsis
- Plankton is important for understanding how metals accumulate and transfer in marine ecosystems, and it can indicate the presence of trace and rare earth elements (REEs).
- A study analyzed phytoplankton from the northwestern Mediterranean Sea and found that metal concentrations varied with season and depth, particularly noting that certain metals were more prevalent in summer and autumn samples at different depths.
- The research indicated that iron, aluminum, and zinc were the most common metals found in phytoplankton, while REE concentrations also peaked in summer and autumn, with the highest total REE levels observed in winter, suggesting that these elements can serve as geological indicators in marine environments.