Publications by authors named "R Murad"
Senescent cells drive tissue dysfunction through the senescence-associated secretory phenotype (SASP). We uncovered a central role for mitochondria in the epigenetic regulation of the SASP, where mitochondrial-derived metabolites, specifically citrate and acetyl-CoA, fuel histone acetylation at SASP gene loci, promoting their expression. We identified the mitochondrial citrate carrier (SLC25A1) and ATP-citrate lyase (ACLY) as critical for this process.
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- The study aimed to improve a standard questionnaire on sexual practices and health outcomes for better understanding across different cultures by assessing participants' willingness to answer and how they interpreted the questions.
- Researchers conducted 645 cognitive interviews in 19 countries between March 2022 and March 2023, gathering diverse perspectives to identify misunderstandings and barriers in responding to the questionnaire.
- The results showed that most participants were open to discussing sensitive topics, leading to necessary revisions in the questionnaire to enhance clarity and cultural relevance, ultimately making it more accessible to a global audience.
Elevated expression of components of eIF4F translation initiation complex has been documented in cancer, resulting in enhanced translation of mRNAs encoding pro-tumorigenic factors, including oncogenic proteins. We previously identified SBI-756, a small molecule that interferes with the eIF4F assembly and overcomes melanoma resistance to BRAF inhibitors. SBI-756 enhanced anti-tumor immunity in pancreatic cancer and was effective in the treatment of diffuse large B cell lymphoma.
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- * Aged individuals showed an increase in macrophages with a tolerogenic phenotype and dysfunctional CD8-positive T cells, while profibrotic macrophages were reduced.
- * Inhibiting TREM1 decreased melanoma growth in younger mice, whereas inhibiting TREM2 helped prevent lung metastasis in older mice, suggesting new treatment targets for age-related melanoma immunotherapy.