Publications by authors named "R Munro Ford"
Adenosine triphosphate-binding cassette (ABC) transporters form a ubiquitous superfamily of integral membrane proteins involved in the translocation of substrates across membranes. Human ABC transporters are closely linked to the pathogenesis of diseases such as cancer, metabolic diseases, and Alzheimer's disease. In this study, four ABC transporters were chosen based on (I) their importance in humans and (II) their score in a structural bioinformatics screen aimed at the prediction of crystallisation propensity.
View Article and Find Full Text PDFObjective: To determine if the compensatory reserve algorithm validated in humans can be applied to canines. Our secondary objective was to determine if a simpler waveform analysis could predict the percentage of blood loss volume.
Methods: 6 purpose-bred, anesthetized dogs underwent 5 rounds of controlled hemorrhage and resuscitation while continuously recording invasive arterial blood pressure waveforms in this prospective, experimental study.
Article Synopsis
- Ascochyta blight, caused by a fungal pathogen, significantly threatens the global chickpea industry, particularly affecting Australia’s multimillion-dollar market through disease management costs and yield losses.
- The disease was introduced to Australia in the 1970s and has since established itself with varying levels of aggressiveness among local isolates, including some that can severely impact even resistant chickpea varieties.
- Recent genomic studies of 230 isolates revealed three main genetic clusters and indicated that highly aggressive traits emerged independently multiple times, suggesting that aggressiveness may be influenced by a combination of minor genetic factors and epigenomic variations.
Long-term Morbidity of Traumatic Brain Injury Following Facial Fracture.
Plast Reconstr Surg Glob Open
November 2024
Background: Traumatic brain injury (TBI) is underreported in craniofacial trauma patients, and the long-term morbidity of TBI associated with craniofacial trauma is poorly defined. Current literature is limited in scope to TBI identification in the immediate posttrauma time frame.
Methods: A retrospective, cohort analysis of adult facial fracture patients presenting from February 2022 to February 2023 was performed.
ABCB6 has been implicated in dyschromatosis universalis hereditaria, a condition characterized by hyperpigmented and hypopigmented skin macules. Dyschromatosis universalis hereditaria can also present with hearing loss. Dyschromatosis universalis hereditaria-associated mutations in ABCB6 have been reported, but the role of this protein in the inner ear has not been studied.
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