Publications by authors named "R Muharam"
Background: Endometriosis is a disease characterized by dysmenorrhea, chronic pelvic pain, and infertility. The pathogenesis of endometriosis and its relationship to infertility are still not fully understood. In vitro fertilization (IVF) is considered an effective treatment for patients with endometriosis-associated infertility.
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- The study investigates the relationship between miR-183 and genes involved in apoptosis and adhesion, which may be important in understanding endometriosis.
- Forty-four participants were analyzed, comparing ectopic endometriosis tissues to healthy endometrial samples, with RNA expression measured through quantitative real-time PCR.
- Although differences in gene expression were found between the two groups, no significant correlation was established between miR-183 and the examined apoptosis and adhesion-related genes in the endometriosis tissue.
Integrated bioinformatic analysis reveals the gene signatures, epigenetic roles, and regulatory networks in endometriosis.
Eur J Obstet Gynecol Reprod Biol
November 2024
Article Synopsis
- The study investigates endometriosis, a prevalent gynecological condition, focusing on the role of gene expression and epigenetic changes in its development, aiming to identify key genes and regulatory networks involved.
- Researchers utilized various microarray and RNA sequencing datasets to analyze differentially expressed genes (DEGs) and identified 551 common DEGs, including changes in mRNA, miRNA, and lncRNA, to better understand the molecular basis of the disease.
- The findings indicate that these DEGs are mainly linked to crucial biological processes such as ECM interaction and P53 signaling pathways, revealing significant hub genes that could be targeted for further research and potential therapeutic approaches.
Background: Since kisspeptin () in the hypothalamus is affected by the inhibitory effect of dynorphin, it raises questions about the controlled balance of these 2 neuropeptides in women with and without polycystic ovary syndrome (PCOS).
Objective: This study compares the expression levels of , dynorphin, neurokinin-B, leptin, and neuropeptide-Y in women with and without PCOS.
Materials And Methods: In this cross-sectional study, the peripheral blood samples of 20 women with PCOS and 20 women without PCOS who referred to Yamin Kencana Clinic, Cipto Mangunkusumo hospital, Jakarta, Indonesia were enrolled from August-December 2022.
The Efficacy and Safety of DLBS3233, A Combined Bioactive Fraction of and speciosa Plants on The Endocrine-Metabolic Profile of Women with Polycystic Ovary Syndrome: A Randomized Clinical Trial.
Int J Fertil Steril
July 2024
Background: A bioactive fraction of and speciosa, DLBS3233, has recently been used for type-2-diabetes treatment due to its favorable effect on insulin sensitivity. The insulin resistance leading to metabolic syndrome is closely linked to hyperandrogenemia in polycystic ovary syndrome (PCOS). This study evaluated the metabolic and reproductive efficacy and safety of DLBS3233 in insulin-resistant PCOS women.
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