Publications by authors named "R Moverare"
The mouse monoclonal antibody 4E3 is specific for the G1m17 allotype of human IgG1.
J Immunol Methods
November 2024
Allotype is an amino acid variation within the immunoglobulin isotypes. Four allotypes have been described for human IgG1 and two of them (G1m3 and G1m17) are located at position 214 in the CH1 region of the gamma chain. Various diseases have been associated with allotype expression, making the allotype research an interesting field in immunology.
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- Monitoring anti-drug antibodies (ADAs) to medications like infliximab and adalimumab is essential for managing treatment in autoimmune disorders and requires detecting these antibodies even when drug levels are present.
- Two new automated ImmunoCAP™ immunoassays were developed to measure serum ADAs without needing a complicated acid-dissociation step and show good precision and the ability to differentiate between antibodies for the two drugs.
- Although the quantitative results from these new assays are not directly comparable to existing tests, they demonstrate a strong qualitative agreement when identifying positive and negative patient samples and may face interference from factors like biotin and rheumatoid factors.
Article Synopsis
- Neutrophilic calprotectin (CP), myeloperoxidase (MPO), neutrophil gelatinase-associated lipocalin (NGAL), and eosinophil-derived neurotoxin (EDN) are potential markers for gut inflammation, but data supporting MPO, NGAL, and EDN is lacking.
- A study involving adult patients assessed these markers in fecal and serum samples to distinguish between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), finding significant differences in protein concentrations.
- Results indicated that fecal MPO and serum NGAL are effective biomarkers for differentiating IBD from IBS, with MPO showing the highest sensitivity and specificity, while serum NGAL was able to predict
Background: Chronic airflow limitation (CAL) is a hallmark of chronic obstructive pulmonary disease but is also present in some patients with asthma. We investigated respiratory symptoms, sleep and health status of participants with and without CAL with particular emphasis on concurrent asthma using data from adult populations in Iceland, Estonia and Sweden investigated within the Burden of Obstructive Lung Disease study.
Methods: All participants underwent spirometry with measurements of forced expiratory volume in 1 s (FEV) and forced vital capacity (FVC) before and after bronchodilation.