Publications by authors named "R Morikawa"
Background: Gastrointestinal (GI) toxicities are among the most common and potentially severe immune-related adverse events (irAEs), and data on risk factors remain limited. This study aimed to identify risk factors for GI-irAEs in patients treated with ICIs.
Research Design And Methods: We conducted a retrospective analysis of patients with any type of malignant tumor who received ICIs between January 2020 and January 2022.
Aim: Whole-exome sequencing (WES) studies have revealed that germline de novo variants (gDNVs) contribute to the genetic etiology of schizophrenia. However, the contribution of mosaic DNVs (mDNVs) to the risk of schizophrenia remains to be elucidated. In the present study, we systematically investigated the gDNVs and mDMVs that contribute to the genetic etiology of schizophrenia in a Japanese population.
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- Feedback at the photoreceptor synapse plays a crucial role in visual processing by influencing how visual signals are processed in the brain.
- Researchers found that the electrogenic bicarbonate transporter Slc4a5 in mouse horizontal cells is essential for this feedback, while another transporter, Slc4a3, is not involved.
- Their findings suggest that changes in the voltage of horizontal cells affect bicarbonate transport to cones, indicating a unique mechanism at this initial stage of visual synapse activity.
Loss to follow-up among adults with drug-resistant TB in Papua New Guinea.
Public Health Action
September 2024
Setting: Multidrug-resistant/rifampicin-resistant TB (MDR/RR-TB) is now endemic in the National Capital District (NCD), Papua New Guinea. Loss to follow-up (LTFU) is a challenge.
Objective: To evaluate and identify risk factors for LTFU, including pre-treatment LTFU, in adults with MDR/RR-TB at Port Moresby General Hospital (PMGH).
Article Synopsis
- Sildenafil improves insulin sensitivity and enhances insulin secretion in β cells, particularly in the presence of other depolarizing stimuli.
- The drug operates independently of the traditional PDE5/cGMP pathway, primarily by increasing calcium influx through R-type voltage-dependent calcium channels.
- This study positions sildenafil as a potential antidiabetic medication and provides insights into a novel mechanism for insulin secretion.