Publications by authors named "R Morell"

Article Synopsis
  • * In experiments on mice and human subjects, Dex-CI showed a significant reduction in electrical impedance and inflammatory response compared to standard implants.
  • * Locally delivered dexamethasone (Dex-local) was found to be ineffective for long-term improvement, indicating that Dex-CI is a better option than current clinical practices for reducing inflammation and improving implant performance.
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Article Synopsis
  • - Digital technologies show potential for improving health, but their application for young people with mental illnesses is not fully understood.
  • - A study involving 492 young people with mental illness tested four types of health apps, revealing a strong preference for tracking physical activity, sleep, and diet.
  • - Participants suggested that ideal apps should integrate physical and mental health tracking and feature expert-led content, highlighting a lesser interest in sharing data with healthcare providers.
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Objective: To examine the accuracy and likely clinical usefulness of the Psychosis Metabolic Risk Calculator (PsyMetRiC) in predicting up-to six-year risk of incident metabolic syndrome in an Australian sample of young people with first-episode psychosis.

Method: We conducted a retrospective study at a secondary care early psychosis treatment service among people aged 16-35 years, extracting relevant data at the time of antipsychotic commencement and between one-to-six-years later. We assessed algorithm accuracy primarily via discrimination (C-statistic), calibration (calibration plots) and clinical usefulness (decision curve analysis).

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Deafness in vertebrates is associated with variants of hundreds of genes. Yet, many mutant genes causing rare forms of deafness remain to be discovered. A consanguineous Pakistani family segregating nonsyndromic deafness in two sibships were studied using microarrays and exome sequencing.

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