Publications by authors named "R Mooney"
Background: The Covid-19 pandemic showed higher infection, severity and death rates among those living in poorer socioeconomic conditions. We use syndemic theory to guide the analyses to investigate the impact of social adversity and multiple long-term conditions (MLTC) on Covid-19 mortality.
Methods: The study sample comprised 154 725 UK Biobank participants.
Socially effective vocal communication requires brain regions that encode expressive and receptive aspects of vocal communication in a social context-dependent manner. Here, we combined a novel behavioral assay with microendoscopy to interrogate neuronal activity in the posterior insula (pIns) in socially interacting mice as they switched rapidly between states of vocal expression and reception. We found that distinct but spatially intermingled subsets of pIns neurons were active during vocal expression and reception.
View Article and Find Full Text PDFBackground: CPT codes for ventral hernia repair (VHR) changed in January 2023 to address the heterogeneity of procedures with a concomitant shift from a 90-day to a 0-day global period. This study reviews a tertiary referral center's experience with hernia coding comparing the work relative value units (wRVUs) generated for ventral hernia repair pre-2023 compared to post-2023.
Study Design: CPT codes were analyzed for patients undergoing open or laparoscopic VHR before updates to the CPT hernia codes (January 2022-September 2022) and following CPT change (January 2023-September 2023).
Objective: After severe corticospinal tract damage poststroke in humans, some recovery of strength and movement proximally is evident. It is possible that alternate motor pathways, such as the reticulospinal tract, may be upregulated to compensate for the loss of corticospinal tract input. We investigated the extent of reticulospinal tract excitability modulation and its inter-dependence on the severity of corticospinal tract damage after stroke in humans.
View Article and Find Full Text PDFArticle Synopsis
- The biogenesis of RNA by RNA polymerase (RNAP) requires specific accessory factors for regulating various stages of transcription, with NusG-Spt5 being the only universally conserved factor across all life forms.
- NusG-Spt5's evolution has enabled it to maintain important interactions with RNAP, influencing transcription processes by either reducing or increasing pausing during RNA elongation based on the strength of its binding.
- Recent research has uncovered the functional diversity of NusG-Spt5 among different organisms, showing variations in their target selection and roles in regulating critical biological processes, such as the production of antibiotics and toxins.