HLA EPLET Frequencies Are Similar in Six Population Groups and Are Expressed by the Most Common HLA Alleles.

The degree of immunological compatibility between donors and recipients greatly impacts allograft survival. In the United States kidney allocation system, HLA antigen-level matching has been shown to cause ethnic disparities and thus, has been de-emphasised. However, priority points are still awarded for antigen-level zero-ABDR matching, zero-DR matching and one-DR matching.

: An R Package to Calculate ActiGraph Activity Counts From Portable Accelerometers.

Portable accelerometers are used to capture physical activity in free-living individuals with the ActiGraph being one of the most widely used device brands in physical activity and health research. Recently, in February 2022, ActiGraph published their activity count algorithm and released a Python package for generating activity counts from raw acceleration data for five generations of ActiGraph devices. The nonproprietary derivation of the ActiGraph count improved the transparency and interpretation of accelerometer device-measured physical activity, but the Python release of the count algorithm does not integrate with packages developed by the physical activity research community using the R Statistical Programming Language.

Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping.

Hospitalized COVID-19 patients exhibit diverse immune responses during acute infection, which are associated with a wide range of clinical outcomes. However, understanding these immune heterogeneities and their links to various clinical complications, especially long COVID, remains a challenge. In this study, we performed unsupervised subtyping of longitudinal multi-omics immunophenotyping in over 1,000 hospitalized patients, identifying two critical subtypes linked to mortality or mechanical ventilation with prolonged hospital stay and three severe subtypes associated with timely acute recovery.

Balancing equity and human leukocyte antigen matching in deceased-donor kidney allocation with eplet mismatch.

Human leukocyte antigen-level matching in US kidney allocation has been deemphasized due to its role in elevating racial disparities. Molecular matching based on eplets might improve risk stratification compared to antigen matching, but the magnitude of racial disparities in molecular matching is not known. To assign eplets unambiguously, we utilized a cohort of 5193 individuals with high-resolution allele-level human leukocyte antigen genotypes from the National Kidney Registry.