Background: In recent decades, anti-angiogenic treatment strategy has been well described in cancer treatment. The anti-angiogenic activity of both bevacizumab and aflibercept has been researched on 10 previously established primary oral squamous cell carcinoma (OSCC) cells of an Iranian population with different levels of purity, in an attempt to find the most effective anti-angiogenic-targeted drug.
Methods: To investigate and compare the effect of bevacizumab and aflibercept on vascular endothelial growth factor (VEGF) secretion of 10 primary OSCC cells, cell proliferation and viability were assessed by ELISA and MTT assays.
Objective: To evaluate the effect of preoperative intravitreal bevacizumab (IVB) injection on the rate of early (< or =4 weeks) postvitrectomy hemorrhage in patients with proliferative diabetic retinopathy (PDR).
Design: Prospective, randomized, double-masked clinical trial.
Participants: Sixty-eight eyes of 68 patients undergoing pars plana vitrectomy for management of PDR complications.
Eur J Ophthalmol
November 2006
Purpose: To report the development of extensive fibrovascular proliferation in association with Nocardia subretinal abscess.
Method: Case report.
Results: Extensive retinal neovascularization with tractional retinal detachment developed soon after ocular involvement in a 61-year-old patient with systemic nocardiosis.
Purpose: To study the characteristics and outcomes of choroidal neovascularization (CNV) developing after surgery for idiopathic macular holes.
Methods: Retrospective, noncomparative case series. Search of diagnostic and procedure databases of four participating institutes identified nine eyes of eight patients with CNV after surgery for idiopathic macular hole.