Publications by authors named "R Monreal Robles"
Objective: The diagnosis of secondary progressive multiple sclerosis (SPMS) is often established retrospectively leading to a delay in detection. This work presents a clinical care algorithm that aims to facilitate the recognition of the secondary progressive phase of the disease, analyzing its usefulness and the feasibility of its implementation in routine clinical practice.
Methods: The algorithm was developed in four phases: 1) choice of validated diagnostic tools for the detection of progression; 2) assessment of these tools based on experience of use, applicability, time consumed, perceived usefulness and suitability for a profile of a patient in transition to SPMS; 3) framework and final sequence of application; 4) feasibility evaluation through application in clinical practice.
Article Synopsis
- * Using integrative taxonomy, both morphological and mitochondrial genetic analyses were performed, revealing that neither Leptalpheus nor Fenneralpheus forms monophyletic groups, but confirming three distinct clades of Leptalpheus.
- * Three new shrimp species were identified, including Leptalpheus ankeri from the Caribbean and L. sibo from Nicaragua, and several taxonomical revisions were made regarding previously described species, highlighting their evolutionary relationships and morphological similarities
Article Synopsis
- - Long COVID is a long-lasting illness that can cause significant health issues over time.
- - While there has been some improvement in understanding long COVID, there are currently no approved treatments available.
- - Engaging patients as active partners in research can help close the gap between patients and researchers, speeding up the development of effective treatments and cures.
Help-seeking barriers differ according to the sociocultural context and country-specific mental healthcare system. More research is needed in low-middle-income countries, where early psychosis programs are still scarce, and the mental health care gap is wide. This study aims to explore predisposing, enabling, and need factors associated with mental health service utilization in 481 Mexicans self-reporting psychosis risk symptoms, as well as differences between those who were currently mental health service users (MHSU) and those who were not (non-MHSU).
View Article and Find Full Text PDFNMR utilization in fragment-based drug discovery requires techniques to detect weakly binding fragments and to subsequently identify cooperatively binding fragments. Such cooperatively binding fragments can then be optimized or linked in order to develop viable drug candidates. Similarly, ligands or substrates that bind macromolecules (including enzymes) in competition with the endogenous ligand or substrate are valuable probes of macromolecular chemistry and function.
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