The effects of short bouts of ergometric exercise for severely burned children in intensive care: A randomized controlled trial.

Objective: To determine the effects of short bouts of ergometric exercises on the number of days in the burn intensive care unit (ICU), body mass, and functional ambulation.

Design: Multi-center, randomized controlled trial.

Setting: Burn intensive care unit.

Clearance of Indocyanine Green in Severe Pediatric Burns.

Background: Clearance of indocyanine green dye (ICGc) reflects sinusoidal perfusion and hepatocyte cell membrane function. Thus, ICGc is a reflection of the functional reserve of intact hepatocytes. The purpose of this study was to identify predictors of ICGc in severely burned children during the acute hospitalization and at the time of discharge from the intensive care unit (ICU).

Production and transplantation of bioengineered lung into a large-animal model.

The inability to produce perfusable microvasculature networks capable of supporting tissue survival and of withstanding physiological pressures without leakage is a fundamental problem facing the field of tissue engineering. Microvasculature is critically important for production of bioengineered lung (BEL), which requires systemic circulation to support tissue survival and coordination of circulatory and respiratory systems to ensure proper gas exchange. To advance our understanding of vascularization after bioengineered organ transplantation, we produced and transplanted BEL without creation of a pulmonary artery anastomosis in a porcine model.

Estimated versus achieved maximal oxygen consumption in severely burned children maximal oxygen consumption in burned children.

Purpose: In burned children, exercise training increases maximal oxygen consumption (VO max) and can be combined with the nonspecific beta-blocker propranolol to decrease cardiac work. VO max is estimated if indirect calorimetry is not available. We compared measured and estimated VO max in severely burned children treated with or without propranolol to determine the suitability of commonly used formulas in these populations.