Publications by authors named "R Misir"
Biosolids has several challenges, such as its high water content, huge volume, odour, and pathogen presence. Regulations require biosolids to be reused and disposed of safely. Polymer conditioning focuses on volume reduction, leaving pathogen and odour reduction unaddressed.
View Article and Find Full Text PDFBrain region- and cell-specific transcriptomic and epigenomic features are associated with heritability for neuropsychiatric traits, but a systematic view, considering cortical and subcortical regions, is lacking. Here, we provide an atlas of chromatin accessibility and gene expression profiles in neuronal and non-neuronal nuclei across 25 distinct human cortical and subcortical brain regions from 6 neurotypical controls. We identified extensive gene expression and chromatin accessibility differences across brain regions, including variation in alternative promoter-isoform usage and enhancer-promoter interactions.
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- The study investigates how genetic variants in specific brain cell regulatory elements contribute to disease risk by analyzing chromatin accessibility in neurons and non-neurons from human brain samples.
- Researchers found 34,539 open chromatin areas, with only 10.4% being common between neuron and non-neuron cells, indicating that genetic regulation varies by cell type.
- By identifying 476 regulatory variants with functional impacts, the research enhances understanding of brain gene regulation and its link to diseases, offering valuable insights into potential therapeutic targets.
Non-coding variants increase risk of neuropsychiatric disease. However, our understanding of the cell-type specific role of the non-coding genome in disease is incomplete. We performed population scale (N=1,393) chromatin accessibility profiling of neurons and non-neurons from two neocortical brain regions: the anterior cingulate cortex and dorsolateral prefrontal cortex.
View Article and Find Full Text PDFNon-coding variants increase risk of neuropsychiatric disease. However, our understanding of the cell-type specific role of the non-coding genome in disease is incomplete. We performed population scale (N=1,393) chromatin accessibility profiling of neurons and non-neurons from two neocortical brain regions: the anterior cingulate cortex and dorsolateral prefrontal cortex.
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