Publications by authors named "R Miquel"
The maintenance of stable allograft status in the absence of immunosuppression (IS), known as operational tolerance, can be achieved in a small proportion of liver transplant recipients, but we lack reliable tools to predict its spontaneous development. We conducted a prospective, multicenter, biomarker-strategy design, IS withdrawal clinical trial to determine the utility of a predictive biomarker of operational tolerance. The biomarker test, originally identified in a patient cohort with high operational tolerance prevalence, consisted of a 5-gene transcriptional signature measured in liver tissue collected before initiating IS weaning.
View Article and Find Full Text PDFThe global burden of liver cancer is increasing. Timely diagnosis is important for optimising the limited available treatment options. Understanding the metabolic consequences of hepatocellular carcinoma (HCC) may lead to more effective treatment options.
View Article and Find Full Text PDFArticle Synopsis
- - The Banff Working Group on Liver Allograft Pathology convened in September 2022 with a diverse group of experts to discuss long-term health monitoring of liver transplants, focusing on noninvasive methods and optimizing immunosuppression.
- - The group considered revising the rejection classification scheme to better identify and communicate late T cell-mediated rejection patterns and related changes, like nodular regenerative hyperplasia.
- - They emphasized the need for personalized immunosuppression strategies based on individual patient needs and proposed incorporating interface hepatitis and fibrosis staging into the rejection classification, which will undergo further testing and discussion before the next conference.
Objectives: We aimed to assess the feasibility and reliability of sequential ultrasonographic and elastographic monitoring in acute liver failure (ALF).
Design: Observational study.
Setting: ALF is a rare, life-threatening disease that requires intensive care admission and often liver transplant, where the accurate selection of patients is crucial.