Publications by authors named "R Michael Kuester"
Background: The evidence base supports effectiveness of dental sealants for prevention of childhood caries in school-aged children.
Objective: This study describes planning, development, usability testing and outcomes following implementation of DentaSeal, a web-based application designed to accurately track unique student data and generate reports for all Wisconsin school-based sealant placement (SP) programs.
Methods: Application software development was informed by a steering committee of representative stakeholders who were interviewed to inform design and provide feedback for design of DentaSeal during development and evaluation.
: Pancreatic ductal adenocarcinoma (PDAC) has the lowest five-year survival rate of all cancers in the United States. Programmed death 1 receptor (PD-1)-programmed death ligand 1 (PD-L1) immune checkpoint inhibition has been unsuccessful in clinical trials. Myeloid-derived suppressor cells (MDSCs) are known to block anti-tumor CD8+ T cell immune responses in various cancers including pancreas.
View Article and Find Full Text PDFObjective: To evaluate safety and effectiveness of adalimumab (ADA) in polyarticular-course juvenile idiopathic arthritis (JIA) in the STRIVE registry.
Methods: STRIVE enrolled patients with polyarticular-course JIA into 2 arms based on treatment with methotrexate (MTX) alone or ADA with/without MTX (ADA ± MTX). Adverse events (AEs) per 100 patient-years of observation time were analyzed by registry arm.
Objective: Evolving inflammatory bowel disease (IBD) is a matter of interest in patients with juvenile idiopathic arthritis (JIA) and might be associated with JIA therapy.
Methods: Data from the German biologics registry (Biologika in der Kinderrheumatologie; BiKeR) from 2001 to 2013 were analyzed.
Results: There were 3071 patients with 8389 patient-years (PY) of observation followed.
Article Synopsis
- The study focuses on granulomatosis with polyangiitis (GPA) in children, analyzing data from 56 pediatric patients diagnosed before age 18.
- Most of the patients were female (68%) and Caucasian (82%), with a median diagnosis age of around 11.7 years and an average diagnosis delay of 4.2 months.
- Clinical signs were predominantly seen in the ears, nose, throat, and respiratory system, with a notable percentage of patients testing positive for ANCA-PR3 and presenting with haematuria/proteinuria, showing different patterns of organ involvement compared to adults.