Publications by authors named "R Michael Gower"
Article Synopsis
- - Muscle atrophy due to disuse, aging, or illness can lead to increased risks of injury and prolonged recovery, with macrophages playing a crucial role in muscle regeneration by releasing insulin-like growth factor 1 (IGF-1).
- - Researchers encapsulated all-trans retinoic acid (ATRA) in microparticles to improve its bioavailability and promote IGF-1 release from macrophages, enhancing muscle cell formation and regeneration.
- - The study shows that ATRA-PLG microparticles are effectively taken up by macrophages and can stimulate IGF-1 production, supporting further research on its potential use in muscle recovery treatments.
Article Synopsis
- * Results showed that both doses of sebetralstat provided significantly quicker relief from symptoms and attack severity compared to the placebo, with median times to relief around 1.6-1.8 hours versus over 6 hours for placebo.
- * The trial included 136 participants who treated 264 attacks, demonstrating that sebetralstat could potentially offer a more convenient oral alternative to current parenteral treatments for hereditary angioedema.
Background: Berotralstat is a first-line, once-daily oral plasma kallikrein inhibitor approved for prophylaxis of hereditary angioedema (HAE) attacks in patients 12 years or older.
Objective: This analysis examined the safety and effectiveness of long-term prophylaxis with berotralstat.
Methods: APeX-2 was a phase 3, parallel-group, multicenter trial in patients with HAE caused by C1-inhibitor deficiency (NCT03485911).