Publications by authors named "R Messerer"
Objective: Spinal extradural arachnoid cysts (SEDC) are rare primary spinal lesions, accounting for less than 1% of all spinal epidural lesions. The literature contains only case reports of this pathology, and treatment remains controversial due to its rarity. Major reported SEDC cases are caused by leaking out of cerebrospinal fluid through a dural defect in the thecal sac forming an extradural cyst.
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- Thoracic disc herniation (DH) is a rare but serious condition, and treatment can lead to complications like dural tears, which may cause spinal cord issues.
- A 28-year-old male who previously had surgery for T6-7 DH developed severe symptoms, including paraplegia, due to a transdural herniation of the spinal cord.
- After a multidisciplinary evaluation, the patient underwent further surgery that resulted in some improvement in his condition, highlighting the complexities and risks associated with thoracic disc surgeries.
The muscarinic M acetylcholine receptor is an important drug target for the treatment of various neurological disorders. Designing M receptor-selective drugs has proven challenging, mainly due to the high conservation of the acetylcholine binding site among muscarinic receptor subtypes. Therefore, less conserved and topographically distinct allosteric binding sites have been explored to increase M receptor selectivity.
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- - We created new hybrid compounds (7-C8, 7-C10, 7-C12, 8-C8, 8-C10, 8-C12) that combine features of xanomeline, a muscarinic agonist, and tacrine, an acetylcholinesterase (AChE) inhibitor, linked by a variable-length chain.
- - The new compounds exhibited similar or enhanced AChE inhibition compared to tacrine and were analyzed using docking studies to understand their efficacy.
- - We investigated the interaction with muscarinic receptors, revealing that while prior derivatives (6-C7, 6-C10) acted as partial agonists, our new xanomeline-based hybrids (7-C
Purpose: Few published articles have explicitly focused on cysts associated with intramedullary (IM) ependymomas. The objective was to assess the clinical, MRI, and oncological results of patients operated for an IM ependymoma associated with a cystic portion.
Methods: During the study period, 23 IM tumors resected were cystic ependymomas.