Publications by authors named "R Men"
Dyskalemia are associated with an increased risk of mortality in patients undergoing maintenance hemodialysis (MHD). However, studies evaluating the impact of serum potassium variability on mortality in MHD patients are scarce. To investigate serum potassium variability and its association with prognosis in MHD patients, we conducted a retrospective study on maintenance hemodialysis patients from three campus of Renji Hospital between June 2018 and December 2022.
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- Dysregulated T-cell immune responses contribute significantly to various liver diseases, but the mechanisms controlling liver immune balance and specific therapies to manage T-cell overactivation are poorly understood.
- The study analyzed metabolic changes in ConA mice and autoimmune hepatitis patients, focusing on purine metabolism and its link to liver injury, highlighting the increased expression of purine catabolism nucleases CD39 and CD73 during liver injury.
- Findings indicate that a specific subset of cells, called MCregs, can suppress CD4 T-cell overactivation and liver damage by releasing extracellular vesicles that convert AMP to immunosuppressive metabolites, suggesting that MCreg or MCreg-EV therapy could be effective in treating liver diseases linked to T-cell overactivation.
[Response to Primary Biliary Cholangitis Treatment: Influencing Factors and the Role in Prognosis Prediction].
Sichuan Da Xue Xue Bao Yi Xue Ban
September 2023
Objective: To examine the influencing factors and prognostic features of poor response to ursodeoxycholic acid (UDCA) treatment in primary biliary cholangitis (PBC) patients with dyslipidemia.
Methods: A retrospective study was conducted, covering 512 patients who had a confirmed diagnosis of PBC, and who received treatment at West China Hospital, Sichuan University between January 2009 and March 2022. According to their actual response to UDCA treatment, patients were divided into two groups, UDCA full-response group ( =305) and UDCA non-responding group ( =207).